- EA Replay
- Earth Defense Forces 2 Portable (Japan)
- Echochrome (Europe)
- Echoshift (Europe)
- Eien no Aseria - Kono Daichi no Hate de (Japan)
- Eiyuu Densetsu - Ao no Kiseki (Japan)
- Eiyuu Densetsu - Zero no Kiseki (Japan)
- Elkrone no Atelier - Dear For Otomate (Japan)
- Elminage Gothic - Ulm Zakir to Yami no Gishiki Japan
- Elminage Ibun - Ame no Mihashira Japan
- Elminage III - Ankoku no Shito to Yaiyou no Kyuuden (Japan)
- Enkaku Sousa - Sana E no 23 Hiai (Japan)
- Eragon
- Eternal Etude - Canvas 4 (Japan)
- Evangelion - Jo (Japan)
- Ever17 - The Out of Infinity Premium Edition (Japan)
- Every Extend Extra
- Everybody's Golf (Europe)
- Everybody's Golf 2 (Europe)
- Everybody's Stress Buster (Korea)
- Everybody's Tennis (China)
- Exciting Pro Wrestling 7 - Smackdown! vs. Raw 2006 (Japan)
- Exit
- Exit 2 (Europe)
- Eyepet