- M.A.C.H. - Modified Air Combat Heroes 232MB
- Machi-Ing Maker 3 X Tousouchuu (Japan) 42MB
- Macross Ace Frontier (Japan) 380MB
- Madden NFL 06 1004MB
- Madden NFL 07 1154MB
- Madden NFL 08 852MB
- Madden NFL 09 616MB
- Madden NFL 10 791MB
- Madden NFL 11 456MB
- Madden NFL 12 461MB
- Magic Sudoku (China) 72MB
- Magna Carta Portable (Japan) 1430MB
- Magustale Eternity - Seikaiju to Koisuru Mahou Tsukai (Japan) 1427MB
- Mahjong Haoh Battle Royale II (Japan) 57MB
- Mahjong Kakutou Club (Japan) 124MB
- Mahjong Taikai (Japan) 162MB
- Mahou Shoujo Lyrical Nanoha A's Portable - The Battle of Aces (Japan) 313MB
- Mai-Hime Bakuretsu! Fuuka Gakuen Gekitoushi! (Japan) 231MB
- Major League Baseball 2k10 1167MB
- Makai Senki Disgaea 2 Portable (Japan) 413MB
- Mana Khemia - Student Alliance 508MB
- Manhunt 2 981MB
- Maplus - Portable Navi 787MB
- Marriage Royale - Prism Story (Japan) 1377MB
- Maru Goukaku - Maru Goukaku - Shikaku Dasshu! Shouken Gaimuin Shiken Portable (Japan) 39MB
- Marvel - Ultimate Alliance 1417MB
- Marvel - Ultimate Alliance 2 1413MB
- Marvel Nemesis - Rise of The Imperfects 107MB
- Marvel Super Hero Squad 1232MB
- Marvel Trading Card Game 609MB
- Mashiro Iro Symphony - Mutsu-No-Hana (Japan) 1307MB
- Mawaskes - Based on Carton-Kun (Japan) 84MB
- Me & My Katamari 995MB
- Me de Unou wo Kitaeru - Sokudoku Jutsu Portable (Japan 125MB
- Medal of Honor - Heroes 449MB
- Medal of Honor - Heroes 2 352MB
- Medievil Resurrection 854MB
- Mega Man - Maverick Hunter X 409MB
- Mega Man - Powered Up 257MB
- Meitantei Conan - Kakokara no Zensou Kyoku (Japan) 227MB
- Memories Off - After Rain (Japan) 1035MB
- Memories Off 2nd (Japan) 652MB
- Memories Off Yubikiri no Yakusoku Japan 1065MB
- Mercury 2 For 1 Fun Pack 538MB
- Mercury Meltdown 316MB
- Metal Fight Bayblade Portable - Chouzetsu Tensei Balkan Horuseus (Japan) 178MB
- Metal Gear Acid 2 825MB
- Metal Gear Solid - Digital Graphic Novel 601MB
- Metal Gear Solid - Peace Walker 1417MB
- Metal Gear Solid - Portable Ops 816MB
- Metal Slug Anthology 709MB
- Metal Slug Complete (Japan) 709MB
- Metal Slug XX 195MB
- Miami Vice - The Game 215MB
- Michael Jackson - The Experience 243MB
- Micro Machines V4 255MB
- Midnight Club - L.A. Remix 579MB
- Midnight Club 3 - Dub Edition 958MB
- Midway Arcade Treasures - Extended Play 448MB
- Military History Commander - Europe At War (Europe) 56MB
- Mimana Iyar Chronicle 425MB
- Mind Quiz 35MB
- Minna de Dokusho - Keatai Shousetsu Desu (Japan) 62MB
- Minna no Sukkiri (Japan) 318MB
- MLB 619MB
- MLB 06 - The Show 765MB
- MLB 07 - The Show 848MB
- MLB 08 - The Show 850MB
- MLB 09 - The Show 852MB
- MLB 10 - The Show 856MB
- MLB 11 - The Show 815MB
- Mobile Suit Gundam - Giren no Yabou - Zeon no Keifu (Japan) 1139MB
- Mobile Train Simulator + Densha de Go! Tokyo Kyuukou Hen (Japan) 1515MB
- Modnation Racers 1071MB
- Moe Moe 2-Ji Daisenryaku 2 (Japan) 868MB
- Moeru Mahjong - Moe-Jong (Premium Box) (Japan) 174MB
- Momotarou Dentetsu Tag Match - Yuujou - Doryoku - Shouri no Maki! (Japan) 242MB
- Monochrome 905MB
- Monster Hunter Freedom 618MB
- Monster Hunter Freedom 2 650MB
- Monster Hunter Freedom Unite 763MB
- Monster Hunter Portable Japan 620MB
- Monster Jam - Path of Destruction 199MB
- Monster Jam - Urban Assault 478MB
- Monster Kingdom - Jewel Summoner 477MB
- Mortal Kombat - Unchained 1037MB
- Moto GP 241MB
- Motto Nuga-Cel! (Japan) 337MB
- Moujuutsukai to Oujisama Portable (Japan) 783MB
- MTX Mototrax 821MB
- Mugen Kairou (Japan) 66MB
- Musketeer - Le Sang Des Chevaliers (Japan) 1572MB
- Musou Orochi (China) 445MB
- MVP Baseball 569MB
- MX vs. ATV Reflex 248MB
- My Spanish Coach 108MB
- Myst (Europe) 840MB
- Mytran Wars 787MB
